This guide presents the essential steps for nonprofit organizations to access and manage U.S. government grants. It details the required registrations: CAGE/NCAGE, DUNS and SAM, their processing times and the need for periodic renewals. The document lists essential organizational policies: human resources and salary grid, indirect cost policy, procurement, financial policies, document retention and anti-fraud and anti-corruption. It explains the indirect cost rate options, including the 10% de minimis rate, the flat rate and the negotiated agreement (NICRA), as well as the constraints of applying a uniform rate for all USG grants. Accounting systems, keeping daily timesheets, financial monitoring and the importance of trained staff to manage budgets and expenses are covered. The guide advises on contract negotiations: advances, types of agreements (fixed price versus cost reimbursement), timing and currency of payments, and associated risks. It reminds us that unspent funds must be returned, and lists good internal control practices, such as segregation of duties and signature requirements. The document clarifies USG approval structures (Agreement Officer/Contracting Officer and their representatives) and suggests useful resources and links provided by USAID and other partner organizations. It stresses the need to anticipate registration deadlines, document clear policies and ensure compliance with USG rules. Rigorous preparation, training and record-keeping facilitate ongoing and sustainable compliance.