This guide presents recommendations for designing and disseminating a policy brief aimed at translating scientific knowledge into accessible, actionable messages for decision-makers, practitioners and other users. It defines the policy brief as a concise summary of the state of knowledge on an issue, policy options and recommendations. He identifies common criticisms: excessive length, inaccessible language and jargon limiting understanding by non-researchers. Three steps structure the process: understanding user expectations through regular interaction, structuring the note into clear, brief sections, and validating its relevance with recipients. The recommended structure includes an attractive title, a brief summary, highlights, an introduction, a succinct presentation of the methodological approach, results presented in a simple manner, a conclusion and realistic, contextualized recommendations, with identification of those responsible for implementation. Validation consists of sharing the initial version with the addressees to adjust the content and achieve a match between needs and synthesis. Best practices emphasize the importance of understanding the request, involving recipients from the outset, delivering the note on time, using clear language, limiting methodological details and maintaining an active dialogue to encourage adoption of the recommendations. A checklist accompanies the process. The document states that it was made possible by support from USAID, and is the responsibility of Results for Development, Duke, Feed the Children, Amref, Synergos, RAME, RESADE, CERRHUD and UHF. Practical tools included.